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Sanders'
Psychobiology Research Lab
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322 Olin Hall
Department of Psychology
Drake University
Des Moines, IA 50311
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515-271-2043
515-271-1925 (fax)
brian.sanders@drake.edu
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Lab
Overview |
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The focus of our
current research is on understanding the mechanisms and processes by which
various forms of early experience can alter subsequent biobehavioral responses
to stress. Chronic exposure to stress has been implicated in a variety of
physical (e.g., cardiovascular, respiratory) and psychological (e.g., anxiety,
depression) conditions. Stress is not a unitary phenomenon however, and
although there are some common biological and behavioral response patterns
in most species, each organism responds to stress in a unique manner that
reflects its particular experience life history and genetic code. Thus,
much basic and applied science has focused on understanding the internal
and external forces that modulate the response to stress, which in turn
helps inform us about the etiology of a variety of stress-induced physical
and mental disorders. In our lab, we use animal models with a genetic bias
toward exaggerated cardiobehavioral reactivity to explore how early life
events such as maternal separation or cross-fostering shape future reactions
to stressful or novel situations. Typically, adult subjects are put through
a battery of tests to examine behavioral, cardiovascular, hormonal, and
neurochemical alterations in the stress response that may result from the
interaction of genomic and non-genomic factors. Our current work is funded
by the NIH's National Heart, Lung and Blood Institute. |
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Available
Techniques |
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Behavioral testing;
automated open field chamber for exploratory behavior, automated elevated
plus maze for measuring anxiety-like behavior
Cardiovascular recording;
cardiovascular parameters are measured via indwelling catheter or using
telemetry, depending on the particular experiment
Microdialysis and HPLC;
central dialysate samples are collected and
analyzed for neurochemical (typically dopamine and norepinephrine) levels
in hypothalamic and amygdalar structures.
Immunohistochemistry/Histology;
current work involves using immunhistochemistry to assess level of neuronal
activation as indicated by the expression of the immediate-early gene,
c-Fos. Histological workstations are available for standard verfication
of cannluae and/or electrode placement.
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Current and Recent Students
(who have studied
in the lab and pursued graduate or professional education in a related
area)
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Alan Anticevic; anticipated graduation,
May 2004
Serge Kobsa; MD/PhD program, Yale University
Angela Grippo, PhD; Department of Pharmacology,
Loyola University Medical School
S. Michelle DeFord, PhD; United States
Army Chemical Defense Research Institute
Brian Erling, MD
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